The surname Possanza presents an anthroponymic and nickname origin with different interpretations. In this sense, E. Rossoni notes that it derives from the medieval name Possanza, of an auspicious character, attributed to children with the wish that they be strong and powerful.

For his part, F. De Laurentiis proposes a nickname interpretation, linking it with bynames applied to people of great stature or robust build. In this way, the surname may reflect both a name of symbolic intent and a descriptive designation based on physical characteristics of the bearer.