The surname Ortolani is of occupational origin and derives from the term ortolano, which designates one who cultivates or sells vegetables. On this point E. De Felice and F. De Laurentiis agree, noting that the surname was formed from a nickname linked to this activity, following a common practice in the formation of Italian surnames.

Both authors thus highlight its professional character, reflecting the identification of the founding ancestor with his trade, which led to the fixing of the byname as a hereditary surname.