The surname Ognibene is of anthroponymic origin and derives from a medieval auspicious name expressing a positive wish, with the meaning "may he have all well" or "filled with goods". On this point E. De Felice and F. De Laurentiis agree, noting that the name is documented from the 11th century in Latinized forms such as Omnebene, Omnibene and Omnibonus, reflecting its auspicious character within the onomastic tradition.

Along the same lines, E. Rossoni indicates that the surname derives from modifications of the medieval name Omnibonus, also related to Italian forms such as Onnibene or Tuttobuono. He also supplies historical documentation that confirms its use in different notarial contexts and evidences the evolution of the name into various variants, all of them linked to the original idea of prosperity and well-being.