According to E. De Felice, Ardizzone is a patronymic surname derived from the medieval personal names Ardizzo and Ardizzone, which are ultimately linked to the Germanic root hardhu, meaning “strong,” “brave,” or “courageous.” These names are documented in Italy from the 11th century in Latinized forms such as Ardicio, Arditio, Ardicione, and Ardizonus, as well as in vernacular forms including Ardiccio, Ardiccione, and Ardizzone.

De Felice explains that the name originated as a hypocoristic form built on the root Ard- combined with the Germanic suffix -izo. Over time, as the original Germanic structure became less recognizable, the name was reinterpreted through Italian suffixes such as -izzo and -iccio. He also notes that the surname is documented as early as 1261 in Venice, where a Joannes Ardizon appears among those elected to the Maggior Consiglio. While found throughout Italy in various forms, the surname is especially common in Sicily.

V. Blunda agrees on the Germanic origin and, for the Sicilian form, derives the surname from the personal name Hardizone, an augmentative form of Hardo. He notes that the suffix -one is a common Italian augmentative ending used to emphasize greatness, importance, or strength. Blunda also points out that the variant Cardizzone, featuring an initial C-, is characteristic of medieval Sicilian dialects.

Overall, Ardizzone is a surname derived from an ancient Germanic personal name associated with strength, courage, and valor, originally identifying the descendants of an ancestor bearing the name Ardizzo or Ardizzone.