E. Rossoni considers that this surname is typical of southern Italy, characteristic of the region of Campania, with a presence in the Naples and Salerno areas. According to Rossoni, it could derive from a dialect demonym form of the place name Salza Irpina, in the Avellino area, indicating that town as the place of origin of the families that adopted it.

F. De Laurentiis, on the other hand, proposes a different origin: the surname would be proper to Veneto and would derive directly from the place name Salzano, a locality of the Venice area. Both proposals suggest a toponymic origin, although they point to different regions, which indicates that the surname presents independent origins in different regions of Italy.