The surname Putrino presents a nickname origin with different possible interpretations. In this sense, E. Rossoni proposes a derivation from the Greek poterion ("cup"), which could link the surname with a craft trade, such as that of potter, or with a nickname related to personal habits. He likewise mentions an alternative hypothesis that relates it with the Sicilian word putru.

Along the same lines, V. Blunda develops this last interpretation, noting that it comes from the dialect pùtru ("colt"), applied as a nickname to young, vigorous or lively-natured people. In this way, the surname could reflect both a designation linked to a trade or habit and an affectionate byname based on physical or behavioural characteristics.