The surname Principe is of anthroponymic and nickname origin, derived from the term principe ("prince"), used as a name or byname. On this point E. De Felice and E. Rossoni agree, noting that it could have been used with an auspicious value, as a wish for prestige or social elevation.

E. De Felice adds that it could also have originated in contexts linked to primacies or victories in celebrations, or in relation to people who lived or worked in noble houses. Along the same lines, E. Rossoni highlights its use as a name of good omen or as an indication of dependence on a princely family. In this way, the surname reflects a symbolic or social designation, later fixed as a hereditary surname.