The surname Pisci is of nickname origin and derives from dialect terms meaning 'fish'. On this point E. Rossoni and V. Blunda agree, linking it with the Sardinian and Sicilian word pisci, related to the marine sphere.

E. Rossoni notes that the surname could have originated as a nickname applied to fishermen or people linked to this activity, while V. Blunda reinforces this interpretation by highlighting its use in contexts of fishing tradition, both as an occupational and a descriptive reference. In this way, the surname reflects a designation linked to the environment and the trade, later fixed as a hereditary surname.