The surname Pinzone is of nickname origin and derives from a Sicilian dialect term designating the chaffinch, a small bird with a melodious song. On this point G. P. Holmes and V. Blunda agree, relating it to this reference to the animal world.

V. Blunda notes that it comes from the word pinsùni and that it could have originated as a nickname applied to people with characteristics associated with the bird, such as a pleasant voice or a lively character. In this way, the surname reflects a descriptive designation based on analogies with nature, later fixed as a hereditary surname.