The surname Palese shows an uncertain origin, with different hypotheses proposed by the authors. In this sense, E. Rossoni notes that it could derive from the Greek name Pales, although in some cases it may also be linked with the place name Palese, in the Bari area, which would indicate a geographical origin.

For his part, E. Costantini proposes an alternative interpretation based on documented forms such as Pallesius, suggesting a possible Latinization of earlier expressions such as delle pale, related to a place name that would allude to sloping or grass-covered terrain. In this way, the surname may reflect both an anthroponymic base and a territorial reference, without a single definitive explanation.