The surname Paleologo has an origin of Greek root and can be explained from two interpretations. In this sense, E. De Felice notes that it reflects the surname Palaiologos, belonging to the dynasty that governed the Byzantine Empire between the 13th and 15th centuries, diffused in Europe after the fall of Constantinople.

For his part, E. Rossoni proposes a nickname interpretation, deriving it from the Greek term paleologos ("one who knows ancient things"), compounded of palaios ("ancient") and logos ("discourse" or "knowledge"), which could allude to the trade or the cultural characteristics of the ancestor. In this way, the surname may reflect both a historical heritage linked to the Byzantine world and a nickname of an intellectual character.