The surname Ottone is of anthroponymic origin and derives from the medieval name Ottone, of Germanic root. On this point E. Rossoni and V. Blunda agree, linking it with forms derived from the element aud/od ("wealth", "property", "power"), frequent in early-medieval Germanic onomastics.

E. Rossoni documents its use as early as the Middle Ages and notes its continuity in various variants, while V. Blunda specifies that it is a form expanded with the Italian suffix -one, reinforcing its derived character within this family of names. In this way, the surname reflects the evolution of a Germanic personal name widely diffused in Italy and later fixed as a hereditary surname.