The surname Orazio is of anthroponymic origin and derives from the personal name Orazio, which continues the Latin Horatius, an ancient nomen of classical Rome. In this sense, it can be interpreted as a name of learned tradition, taken up again in the medieval and Renaissance period from the prestige of Latin culture.

The name Horatius has been related to an ancient Roman gens and, from the etymological point of view, has been linked with roots of uncertain meaning, although it is traditionally associated with symbolic or identity values rather than with a precise literal meaning. As a surname, it arises from the transmission of the ancestor's name, following a process usual in the formation of Italian surnames.