This surname would derive from the transformation into a surname of the Piedmontese term cassola, equivalent to the Italian cazzuola (mason's trowel), in turn coming from the medieval Latin cattia, with the meaning of "cup". It would be a reference to an old trade nickname. Its presence is located mainly in the Alessandria area, with concentration in localities such as Acqui Terme, Montechiaro and Ricaldone.

F. De Laurentiis proposes, on the other hand, a toponymic origin, linking the surname to the place name Cazzola, a locality documented in the Parma area and in that of Agrigento.