The surname Bezzi and its variant Bezzo present a multiple origin, with possible derivations both toponymic and anthroponymic and nickname-based. According to E. Rossoni, they can derive from various place names such as Bezzo (in the Verona, Cesena or Savona area), which would indicate the geographical provenance of the lineage. He also notes a possible relation with the name of an old Venetian coin, the bezzo, which suggests an origin as a nickname linked to economic activity or to characteristics associated with money.

In another line of interpretation, E. Rossoni proposes that Bezzi could derive from the Germanic personal name Obizzo or Opizzo, in turn related to the root audha ("wealth"), which introduces an anthroponymic dimension of Germanic origin. This diversity of hypotheses reflects the complexity in the formation of the surname and the overlapping of cultural influences in northern Italy. He also documents its historical presence, as in the case of Lorenzo da Bezzo, parish priest in Rovetta (Bergamo) in the 15th century.

From the geographical point of view, E. Rossoni indicates that Bezzi is spread in the lower Trentino, Lombardy and Emilia, with clusters also in Florence and Rome, while Bezzo is much rarer and is concentrated in the north. For his part, F. De Laurentiis reinforces the nickname hypothesis, considering it derived from the term bezzo, an old Venetian coin. Taken together, the various interpretations agree in pointing to a plural origin, where geographical, personal and economic elements converge in the formation of the surname.