The authors agree that Audisio is a surname derived from a Germanic personal name.

Surnames in Italy considers that Audisio forms part of a broad family of surnames derived from the Germanic name Aldo, originating with the Lombards and spread in Italy by the Franks. The root alda- (German alt, English old) means "old, wise, expert", and remained alive in family onomastics even when the name fell out of use as a given name. The Carolingian epic and the Arthurian cycle reinforced its prestige and turned it into a symbol of medieval status.

Within this family, Audisio is the Piedmontese variant of Aldisio, in turn derived from Aldisius ("old"). It is part of the evolution of the Aud- form, typical of Piedmont and the Naples area, from which Audero also derives. Its distribution is concentrated in Piedmont, especially in the Cuneo and Turin areas, in localities such as Saluzzo and Entracque.

The study of A. Bongioanni, cited by Surnames in Italy, stresses two key phenomena for understanding this type of surname: the survival of Germanic names now out of use as given names in family onomastics, and the influence of the Carolingian epic and the Arthurian cycle, whose literary prestige transformed those names into symbols of medieval status.

V. Blunda approaches the surname from its presence in Sicily and proposes a different etymology. He explains it as a Germanic compound of auda (prosperity, wealth) and wida (knowledge, learning, a root linked to the Germanic verb witan, to know), meaning "prosperous and knowledgeable" or "rich in learning". According to Blunda, the binomial material wealth-learning reflects the ideal of the Lombard chief, in whose authority patrimony and political wisdom converged. He also recalls that it is a surname typical of Piedmont, which reached Sicily with the Gallo-Italic repopulation.