The surname Agrippa has an anthroponymic origin of Latin root, linked to an ancient Roman cognomen. According to E. Rossoni, it derives from Agrippa, a name given to children born "breech" (that is, feet first at birth). This type of naming, based on the circumstances of birth, was common in Roman onomastics. The name is also known through historical figures such as Menenius Agrippa, a famous tribune of the plebs of the 5th century BC.

For his part, A. Bongioanni agrees on its origin as a Latin given name and highlights its continuity in the Christian tradition. He mentions Saint Agrippino of Como, bishop between 607 and 615, and Saint Agrippina of Mineo, venerated as patron of Mineo in Sicily. This religious spread contributed to the name's continued use, especially in southern Italy.

Taken together, both interpretations agree in pointing to an ancient origin linked to the Roman tradition, later reinforced by the Christian cult, with a particular continuity in Sicily and other Italian regions.